Comparison of Survival and Patterns of Recurrence in Gastric Neuroendocrine Carcinoma, Mixed Adenoneuroendocrine Carcinoma, and Adenocarcinoma

作者：Jian‐Xian Lin, Yajun Zhao, Yanbing Zhou, Yantao Tian, Qingliang He, Jun-Peng Lin, Hankun Hao, Bingbing Zou, Lixin Jiang, Gang Zhao, Wei Lin, Yanchang Xu, Zhi Li, Fangqin Xue, Shuliang Li, Weihua Fu, Yongxiang Li, Zekuan Xu, Yong Li, Jinping Chen, Xiaojun Zhou, Zhenggang Zhu, Li‐Sheng Cai, En Li, Honglang Li, Chao‐Hui Zheng, Ping Li, Ze-Ning Huang, Jian‐Wei Xie · 发表于：JAMA Network Open · 年份：2021 · DOI：10.1001/jamanetworkopen.2021.14180 · 被引用次数：62 · 研究领域：Neuroendocrine Tumor Research Advances、Gastric Cancer Management and Outcomes、Metastasis and carcinoma case studies

Importance: Gastric neuroendocrine carcinoma and mixed adenoneuroendocrine carcinoma are rare pathological types of gastric cancer, and there is a lack of multicenter studies comparing the prognosis and recurrence patterns of gastric neuroendocrine carcinoma, gastric mixed adenoneuroendocrine carcinoma, and gastric adenocarcinoma. Objective: To compare the differences in long-term survival and patterns of recurrence among gastric neuroendocrine carcinoma, gastric mixed adenoneuroendocrine carcinoma, and gastric adenocarcinoma. Design, Setting, and Participants: This cohort study included patients with resectable gastric neuroendocrine carcinoma and gastric mixed adenoneuroendocrine carcinoma at 23 hospitals in China from January 2006 to December 2016. In addition, patients with gastric adenocarcinoma were selected as controls. Propensity score-matched analysis was used to match pathological stage among the different pathological types, and disease-free survival (DFS), postrecurrence survival (PRS), and patterns of recurrence were examined. Data analysis was conducted from July 15, 2020, to October 21, 2020. Exposures: Curative resection for gastric neuroendocrine carcinoma, gastric mixed adenoneuroendocrine carcinoma, and gastric adenocarcinoma. Main Outcomes and Measures: The main outcomes were DFS and patterns of recurrence. Results: A total of 3689 patients were analyzed (median [interquartile range] age, 62 [55-69] years; 2748 [74.5%] men), including 503 patients (13.6%) ...