Insight for Immunotherapy of HCMV Infection

作者：Xinmiao Long, Yi Qiu, Zuping Zhang, Minghua Wu · 发表于：International Journal of Biological Sciences · 年份：2021 · DOI：10.7150/ijbs.58127 · 被引用次数：19 · 研究领域：Cytomegalovirus and herpesvirus research、Herpesvirus Infections and Treatments、Immune Cell Function and Interaction

Human cytomegalovirus (HCMV), a ubiquitous in humans, has a high prevalence rate. Young people are susceptible to HCMV infection in developing countries, while older individuals are more susceptible in developed countries. Most patients have no obvious symptoms from the primary infection. Studies have indicated that the virus has gradually adapted to the host immune system. Therefore, the control of HCMV infection requires strong immune modulation. With the recent advances in immunotherapy, its application to HCMV infections is receiving increasing attention. Here, we discuss the immune response to HCMV infection, the immune escape mechanism, and the different roles that HCMV plays in various types of immunotherapy, including vaccines, adoptive cell therapy, checkpoint blockade therapy, and targeted antibodies.