Human milk oligosaccharide 2′-fucosyllactose supplementation improves gut barrier function and signaling in the vagal afferent pathway in mice

作者：Sunhye Lee, Michael L. Goodson, Wendie Vang, Jennifer M. Rutkowsky, Karen M. Kalanetra, Mrittika Bhattacharya, Daniela Barile, Helen E. Raybould · 发表于：Food & Function · 年份：2021 · DOI：10.1039/d1fo00658d · 被引用次数：32 · 研究领域：Gut microbiota and health、Infant Nutrition and Health、Diet and metabolism studies

immunohistochemical detection of c-Fos protein in the brainstem in response to peripheral administration of cholecystokinin (CCK). 2'-FL significantly attenuated the HF-induced increase in fat mass and energy intake. 2'-FL significantly reduced intestinal permeability and significantly increased expression of interleukin (IL)-22, a cytokine known for its protective role in the intestine. Additionally, 2'-FL led to changes in the gut microbiota composition and in the associated microbial metabolites. Signaling in the vagal afferent pathway was improved but there was no effect on cognitive function. In conclusion, 2'-FL supplementation improved the metabolic profiles, gut barrier integrity, lipid metabolism and signaling in the vagal afferent pathway. These findings support the utility of 2'-FL in the control of gut barrier function and metabolic homeostasis under a metabolic challenge.