Immunity and Viral Infections: Modulating Antiviral Response via CRISPR–Cas Systems

作者：Sergey Brezgin, Anastasiya Kostyusheva, Ekaterina O. Bayurova, Elena V. Volchkova, Vladimir Gegechkori, Ilya V. Gordeychuk, Dieter Glebe, Dmitry S. Kostyushev, Vladimir Chulanov · 发表于：Viruses · 年份：2021 · DOI：10.3390/v13071373 · 被引用次数：27 · 研究领域：CRISPR and Genetic Engineering、Viral Infections and Immunology Research、interferon and immune responses

Viral infections cause a variety of acute and chronic human diseases, sometimes resulting in small local outbreaks, or in some cases spreading across the globe and leading to global pandemics. Understanding and exploiting virus-host interactions is instrumental for identifying host factors involved in viral replication, developing effective antiviral agents, and mitigating the severity of virus-borne infectious diseases. The diversity of CRISPR systems and CRISPR-based tools enables the specific modulation of innate immune responses and has contributed impressively to the fields of virology and immunology in a very short time. In this review, we describe the most recent advances in the use of CRISPR systems for basic and translational studies of virus-host interactions.