Correlation analysis of long non‐coding RNA TUG1 with disease risk, clinical characteristics, treatment response, and survival profiles of adult Ph − Acute lymphoblastic leukemia

作者：Pengyun Zeng, Ye Chai, You Chong-ge, Lingling Yue, Chongyang Wu, Huiling Chen, Liangliang Li, Jingjing Li, Huan Liu, Yurong Zhang, Tingyong Cao, Yaru Li, Wanli Hu · 发表于：Journal of Clinical Laboratory Analysis · 年份：2021 · DOI：10.1002/jcla.23583 · 被引用次数：10 · 研究领域：Cancer-related molecular mechanisms research、Acute Lymphoblastic Leukemia research、Lung Cancer Research Studies

Abstract Background Long non‐coding RNA taurine‐upregulated gene 1 (lncRNA TUG1) is reported to be involved in the progression and development of several malignancies; however, its role in Philadelphia chromosome‐negative acute lymphoblastic leukemia (Ph − ALL) is unknown. The present study aimed to explore the correlation of lncRNA TUG1 with disease risk, disease condition, and prognosis of adult Ph − ALL. Methods Total 101 adult Ph − ALL patients and 40 bone marrow (BM) donors were included, followed by detection of BM monocyte cell lncRNA TUG1 expression by reverse transcription‐quantitative polymerase chain reaction. According to the quantiles of lncRNA TUG1 expression in Ph − ALL patients, these patients were divided into four tiers: tier 1 (ranked in 0%~25%), tier 2 (ranked in 25%~50%), tier 3 (ranked in 50%~75%), and tier 4 (ranked in 75%~100%). Results LncRNA TUG1 was upregulated in Ph − ALL patients compared with healthy donors. Further analysis indicated that in Ph − ALL patients, higher lncRNA TUG1 tier was correlated with the presence of central nervous system leukemia, increased white blood cell level, and bone marrow blasts. Furthermore, higher lncRNA TUG1 tier was negatively associated with complete remission (CR) within 4 weeks, total CR, and allogeneic hematopoietic stem cell transplant achievement. In addition, higher lncRNA TUG1 tier was associated with decreased disease‐free survival and overall survival, which was further verified to be an independent fac...