Voltage-Driven Flipping of Zwitterionic Artificial Channels in Lipid Bilayers to Rectify Ion Transport

作者：Zhao-Jun Yan, Yawei Li, Maohua Yang, Yonghong Fu, Rongrong Wen, Wenning Wang, Zhan‐Ting Li, Yunxiang Zhang, Jun‐Li Hou · 发表于：Journal of the American Chemical Society · 年份：2021 · DOI：10.1021/jacs.1c06000 · 被引用次数：62 · 研究领域：Molecular Sensors and Ion Detection、Photoreceptor and optogenetics research、Lipid Membrane Structure and Behavior

We developed a voltage-sensitive artificial transmembrane channel by mimicking the dipolar structure of natural alamethicin channel. The artificial channel featured a zwitterionic structure and could undergo voltage-driven flipping in the lipid bilayers. Importantly, this flipping of the channel could lead to their directional alignment in the bilayers and rectifying behavior for ion transport.