Prevalence of syphilis among men who have sex with men: a global systematic review and meta-analysis from 2000–20

作者：Motoyuki Tsuboi, Jayne Evans, Ella P Davies, Jane Rowley, Eline L. Korenromp, Tim Clayton, Melanie Taylor, David Mabey, R Matthew Chico · 发表于：The Lancet Global Health · 年份：2021 · DOI：10.1016/s2214-109x(21)00221-7 · 被引用次数：255 · 研究领域：Syphilis Diagnosis and Treatment、Reproductive tract infections research、HIV/AIDS Research and Interventions

BACKGROUND: The WHO Global Health Sector Strategy aims to reduce worldwide syphilis incidence by 90% between 2018 and 2030. If this goal is to be achieved, interventions that target high-burden groups, including men who have sex with men (MSM), will be required. However, there are no global prevalence estimates of syphilis among MSM to serve as a baseline for monitoring or modelling disease burden. We aimed to assess the global prevalence of syphilis among MSM using the available literature. METHODS: In this global systematic review and meta-analysis, we searched MEDLINE, Embase, LILACS, and AIM databases, and Integrated Bio-Behavioral Surveillance (IBBS) reports between April 23, 2019, and Feb 1, 2020, to identify studies done between Jan 1, 2000, and Feb 1, 2020, with syphilis point prevalence data measured by biological assay among MSM (defined as people who were assigned as male at birth and had oral or anal sex with at least one other man in their lifetime). Studies were excluded if participants were exclusively HIV-infected MSM, injection-drug users, only seeking care for sexually transmitted infections (STIs) or genital symptoms, or routine STI clinic attendees. Data were extracted onto standardised forms and cross-checked for accuracy and validity. We used random-effects models to generate pooled prevalence estimates across the eight regions of the Sustainable Development Goals. We calculated risk of study bias based on the Appraisal tool for Cross-Sectional Studies, ...