Clot burden of acute pulmonary thromboembolism: comparison of two deep learning algorithms, Qanadli score, and Mastora score

作者：Hongxia Zhang, Cheng Yan, Zhenbo Cheng, Xinying Cong, Kang Han, Rongguo Zhang, Xiaojuan Guo, Min Liu · 发表于：Quantitative Imaging in Medicine and Surgery · 年份：2021 · DOI：10.21037/qims-21-140 · 被引用次数：33 · 研究领域：Venous Thromboembolism Diagnosis and Management

BACKGROUND: The deep learning convolution neural network (DL-CNN) benefits evaluating clot burden of acute pulmonary thromboembolism (APE). Our objective was to compare the performance of the deep learning convolution neural network trained by the fine-tuning [DL-CNN (ft)] and the deep learning convolution neural network trained from the scratch [DL-CNN (fs)] in the quantitative assessment of APE. METHODS: We included the data of 680 cases for training DL-CNN by DL-CNN (ft) and DL-CNN (fs), then retrospectively included 410 patients (137 patients with APE, 203 males, mean age 60.3±11.4 years) for testing the models. The distribution and volume of clots were respectively assessed by DL-CNN(ft) and DL-CNN(fs), and sensitivity, specificity, and area under the curve (AUC) were used to evaluate their performances in detecting clots on a per-patient and clot level. Radiologists evaluated the distribution of clots, Qanadli score, and Mastora score and right ventricular metrics, and the correlation of clot volumes with right ventricular metrics were analyzed with Spearman correlation analysis. RESULTS: On a per-patient level, the two DL-CNN models had high sensitivities and moderate specificities [DL-CNN (ft): 100% and 77.29%; DL-CNN (fs): 100% and 75.82%], and their AUCs were comparable (Z=0.30, P=0.38). On a clot level, DL-CNN (ft) and DL-CNN (fs) sensitivities and specificities in detecting central clots were 99.06% and 72.61%, and 100% and 70.63%, respectively. DL-CNN (ft) sensit...