Association of fluid balance trajectories with clinical outcomes in patients with septic shock: a prospective multicenter cohort study

作者：Meiping Wang, Li Jiang, Bo Zhu, Bin Du, Wen Li, Yan He, Xiuming Xi, China Critical Care Sepsis Trial (CCCST) workgroup, Bin Du, Li Weng, Tong Li, Meili Duan, Wenxiong Li, Bing Sun, Zhou Jian-xin, Jianguo Jia, Xi Zhu, Qingyuan Zhan, Xiaochun Ma, Tiehe Qin, Shou-Hong Wang, Yuhang Ai, Yan Kang, Xue-Lian Liao, Xiangyuan Cao, Yushan Wang, Duming Zhu · 发表于：Military Medical Research · 年份：2021 · DOI：10.1186/s40779-021-00328-1 · 被引用次数：30 · 研究领域：Sepsis Diagnosis and Treatment、Hemodynamic Monitoring and Therapy、Trauma, Hemostasis, Coagulopathy, Resuscitation

BACKGROUND: Septic shock has a high incidence and mortality rate in Intensive Care Units (ICUs). Earlier intravenous fluid resuscitation can significantly improve outcomes in septic patients but easily leads to fluid overload (FO), which is associated with poor clinical outcomes. A single point value of fluid cannot provide enough fluid information. The aim of this study was to investigate the impact of fluid balance (FB) latent trajectories on clinical outcomes in septic patients. METHODS: Patients were diagnosed with septic shock during the first 48 h, and sequential fluid data for the first 3 days of ICU admission were included. A group-based trajectory model (GBTM) which is designed to identify groups of individuals following similar developmental trajectories was used to identify latent subgroups of individuals following a similar progression of FB. The primary outcomes were hospital mortality, organ dysfunction, major adverse kidney events (MAKE) and severe respiratory adverse events (SRAE). We used multivariable Cox or logistic regression analysis to assess the association between FB trajectories and clinical outcomes. RESULTS: Nine hundred eighty-six patients met the inclusion criteria and were assigned to GBTM analysis, and three latent FB trajectories were detected. 64 (6.5%), 841 (85.3%), and 81 (8.2%) patients were identified to have decreased, low, and high FB, respectively. Compared with low FB, high FB was associated with increased hospital mortality [hazard ra...