Pine nut antioxidant peptides ameliorate the memory impairment in a scopolamine-induced mouse model via SIRT3-induced synaptic plasticity

作者：Hongyan Lu, Fang Li, Ji Wang, Fanrui Zhao, Chunlei Liu, Yawen Gao, Jingsheng Liu, Weihong Min · 发表于：Food & Function · 年份：2021 · DOI：10.1039/d1fo01817e · 被引用次数：43 · 研究领域：Biochemical effects in animals、Sirtuins and Resveratrol in Medicine、Neuroscience and Neuropharmacology Research

-induced PC12 cell model, treatment with mitochondrial sirtuin 3 (SIRT3) inhibitor and inducer molecules confirmed that the <3 kDa fraction and WYPGK activated SIRT3, leading to the decrease in Ace-SOD2 acetylation and increasing the expression of SYP, SYN-1, SNAP25, and PSD95, thus enhancing synaptic plasticity. The <3 kDa fraction and WYPGK also activated the ERK/CREB pathway and upregulated the expression of brain-derived neurotrophic factor. Our results show that fraction <3 kDa and WYPGK improve learning and memory ability through SIRT3-induced synaptic plasticity in vitro and in vivo.