Visible-Light-Induced Trifluoromethylation of Allylic Alcohols

作者：Bowen Li, Wubing Zeng, Lin Wang, Zhishuai Geng, Teck‐Peng Loh, Peizhong Xie · 发表于：Organic Letters · 年份：2021 · DOI：10.1021/acs.orglett.1c01767 · 被引用次数：29 · 研究领域：Fluorine in Organic Chemistry、Radical Photochemical Reactions、Sulfur-Based Synthesis Techniques

An organic photoredox-catalyzed dehydroxylative trifluoromethylation of allylic alcohols was developed in an environmentally benign manner. In this reaction, the readily available CF 3 SO 2 Na was selected as the trifluoromethylation reagent. The in situ generated byproduct SO 2 was reutilized to activate C–OH bond, which enabled this dehydroxylative trifluoromethylation to be performed conveniently. A variety of multifunctionalized CF 3 -allylic compounds were obtained in high yields and excellent stereoselectivity.