Brønsted Acid-Catalyzed Minisci-Type Cross-Dehydrogenative Coupling of N -Heteroaromatics and Cyclic Ethers

作者：Zhongxuan Qiu, Pei-Zhen Dong, Huaili Zhao, Zhao Mei-fa, Bin Qiu, Jian Xiao · 发表于：The Journal of Organic Chemistry · 年份：2021 · DOI：10.1021/acs.joc.1c00337 · 被引用次数：19 · 研究领域：Catalytic C–H Functionalization Methods、Synthesis and Biological Evaluation、Synthesis and Catalytic Reactions

-heteroaromatics with cyclic ethers via a cross-dehydrogenative coupling reaction in the presence of benzoyl peroxide was developed. This methodology successfully provided an easy access to a variety of alkyl-substituted quinoxaline, benzoimidazole, pyrazine, pyrimidine, quinoline, isoquinoline, and pyridine derivatives in up to 94% yield under metal-free conditions.