Prognostic and immunological role of CD36: A pan-cancer analysis

作者：Yongjian Chen, Weixin Liao, Shaozhuo Huang, Yunfang Yu, Jing‐Yun Wen, Jie Chen, Dagui Lin, Xiangyuan Wu, Nan Jiang, Xing Li · 发表于：Journal of Cancer · 年份：2021 · DOI：10.7150/jca.50502 · 被引用次数：40 · 研究领域：Cancer, Lipids, and Metabolism、Peptidase Inhibition and Analysis、Ferroptosis and cancer prognosis

CD36 plays a critical role in lipid metabolism, which is closely associated with human immunity. However, the role of CD36 in cancer remains unclear. We performed a pan-cancer analysis to elucidate the potential role of CD36 in cancer by investigating its prognostic value and current predictors for the efficacy of immune checkpoint inhibitors (ICIs) in multiple cancer types. CD36 expression in cancer cell lines, tumor tissue, and their adjacent normal tissues displayed heterogeneity among different cancers. Immunohistochemistry was used to detect CD36 expression and confirmed the results. CD36 expression significantly affects prognosis in the six cancer types. High CD36 expression was marginally associated with poorer prognosis in four of them and improved prognosis in the remaining two types. CD36 expression was significantly correlated with the 6 immune infiltrates in most cancer types. In addition, CD36 gene expression was positively correlated with Stromal score, Immune score, and ESTIMATE score. A total of 47 immune checkpoint genes were collected and their relationship with CD36 expression was analyzed. CD36 expression was significantly associated with multiple stimulatory and inhibitory checkpoint molecules with a disease-specific pattern. As to the genes reported to positively relate to the efficacy of ICIs, CD36 expression was positively correlated with most of them but negatively associated with a small proportion of cancer type-specific patterns. Concerning the gen...