The Influence of Cell Cycle Regulation on Chemotherapy

作者：Ying Sun, Yang Liu, Xiaoli Ma, Hao Hu · 发表于：International Journal of Molecular Sciences · 年份：2021 · DOI：10.3390/ijms22136923 · 被引用次数：294 · 研究领域：Cancer-related Molecular Pathways、Microtubule and mitosis dynamics、Cancer therapeutics and mechanisms

Cell cycle regulation is orchestrated by a complex network of interactions between proteins, enzymes, cytokines, and cell cycle signaling pathways, and is vital for cell proliferation, growth, and repair. The occurrence, development, and metastasis of tumors are closely related to the cell cycle. Cell cycle regulation can be synergistic with chemotherapy in two aspects: inhibition or promotion. The sensitivity of tumor cells to chemotherapeutic drugs can be improved with the cooperation of cell cycle regulation strategies. This review presented the mechanism of the commonly used chemotherapeutic drugs and the effect of the cell cycle on tumorigenesis and development, and the interaction between chemotherapy and cell cycle regulation in cancer treatment was briefly introduced. The current collaborative strategies of chemotherapy and cell cycle regulation are discussed in detail. Finally, we outline the challenges and perspectives about the improvement of combination strategies for cancer therapy.