Validation and Performance of Chronic Liver Disease Questionnaire (CLDQ-RO) in the Romanian Population

作者：Vlad Țâru, Madalin Gabriela Indre, Mina Ignat, Antonnela Forgione, Tamas Racs, Bianca Alina Olar, Oana Nicoară-Farcău, Răzvan Mircea Cherecheș, Horia Ştefănescu, Bogdan Procopeț · 发表于：Journal of Gastrointestinal and Liver Diseases · 年份：2021 · DOI：10.15403/jgld-3405 · 被引用次数：7 · 研究领域：Liver Disease and Transplantation、Hepatitis C virus research、Liver Diseases and Immunity

BACKGROUND AND AIMS: Health-related quality of life is an essential part of managing chronically ill patients, including patients with chronic liver disease. Various methods are used to try to assess the quality of life ranging from generic to disease-specific questionnaires. Some of the results may reveal a novel connection to the disease's evolution, which is observed directly by the patient. This study aimed to validate and assess the chronic liver disease questionnaire (CLDQ-RO) performance in the Romanian population. METHODS: A two-phase study was designed. The first phase consisted of linguistic validation of CLDQ-RO (translation and piloting), while in the second phase, the questionnaire was applied to patients with various chronic liver diseases. Statistical validation (reliability, structural, and construct validity) was performed using SPSS v20.0, and statistical significance was considered p<0.05. RESULTS: The CLDQ-RO was applied to 231 patients with chronic liver disease (14.3% with chronic hepatitis, 35.5% with compensated cirrhosis, and 50.2% with decompensated cirrhosis). The questionnaire showed excellent overall reliability (Cronbach's alpha=0.93) and good structural and construct validity, with most of the items in CLDQ-RO fitting in the domains of the original version of the questionnaire. There was a significant decrease in the overall score of the CLDQ-RO with the progression of disease (p<0.001), indicating a substantial impact of the decompensation even...