Functional human IgA targets a conserved site on malaria sporozoites

作者：Joshua Tan, Hyeseon Cho, Tossapol Pholcharee, Lais S. Pereira, Safiatou Doumbo, Didier Doumtabé, Barbara J. Flynn, Arne Schön, Sachie Kanatani, Samantha O. Aylor, David Oyen, Rachel Vistein, Lawrence Wang, Marlon Dillon, Jeff Skinner, Mary Peterson, Shanping Li, Azza H. Idris, Alvaro Molina-Cruz, Ming Zhao, L. Renee Olano, Patricia Lee, Alison Roth, Photini Sinnis, Carolina Barillas‐Mury, Kassoum Kayentao, Aïssata Ongoïba, Joseph R. Francica, Boubacar Traoré, Ian A. Wilson, Robert A. Seder, Peter D. Crompton · 发表于：Science Translational Medicine · 年份：2021 · DOI：10.1126/scitranslmed.abg2344 · 被引用次数：43 · 研究领域：Malaria Research and Control、HIV Research and Treatment、Complement system in diseases

circumsporozoite protein, the dominant protein on the sporozoite surface. Crystal structures of this antibody revealed a unique mode of binding whereby two Fabs simultaneously bound either side of the target peptide. This study reveals a role for circulating IgA in malaria and identifies the amino terminus of the circumsporozoite protein as a target of functional antibodies.