Recent Advances in Tumor Targeting via EPR Effect for Cancer Treatment

作者：Md Abdus Subhan, Satya Siva Kishan Yalamarty, Nina Filipczak, Farzana Parveen, Vladimir P. Torchilin · 发表于：Journal of Personalized Medicine · 年份：2021 · DOI：10.3390/jpm11060571 · 被引用次数：612 · 研究领域：Nanoparticle-Based Drug Delivery、Nanoplatforms for cancer theranostics、Lanthanide and Transition Metal Complexes

Cancer causes the second-highest rate of death world-wide. A major shortcoming inherent in most of anticancer drugs is their lack of tumor selectivity. Nanodrugs for cancer therapy administered intravenously escape renal clearance, are unable to penetrate through tight endothelial junctions of normal blood vessels and remain at a high level in plasma. Over time, the concentration of nanodrugs builds up in tumors due to the EPR effect, reaching several times higher than that of plasma due to the lack of lymphatic drainage. This review will address in detail the progress and prospects of tumor-targeting via EPR effect for cancer therapy.