Comprehensive Bibliometric Analysis of the Kynurenine Pathway in Mood Disorders: Focus on Gut Microbiota Research

作者：Xiuqing Zhu, Jinqing Hu, Shuhua Deng, Yaqian Tan, Chang Qiu, Ming Zhang, Xiaojia Ni, Haoyang Lu, Zhanzhang Wang, Lu Li, Yayan Luo, Shanqing Huang, Tao Xiao, Shujing Liu, Xiaolin Li, Dewei Shang, Yuguan Wen · 发表于：Frontiers in Pharmacology · 年份：2021 · DOI：10.3389/fphar.2021.687757 · 被引用次数：41 · 研究领域：Tryptophan and brain disorders、Mental Health Research Topics、Gut microbiota and health

Background: Emerging evidence implicates the dysregulated kynurenine pathway (KP), an immune-inflammatory pathway, in the pathophysiology of mood disorders (MD), including depression and bipolar disorder characterized by a low-grade chronic pro-inflammatory state. The metabolites of the KP, an important part of the microbiota-gut-brain axis, serve as immune system modulators linking the gut microbiota (GM) with the host central nervous system. Aim: This bibliometric analysis aimed to provide a first glimpse into the KP in MD, with a focus on GM research in this field, to guide future research and promote the development of this field. Methods: Publications relating to the KP in MD between the years 2000 and 2020 were retrieved from the Scopus and Web of Science Core Collection (WoSCC), and analyzed in CiteSpace (5.7 R5W), biblioshiny (using R-Studio), and VOSviewer (1.6.16). Results: In total, 1,064 and 948 documents were extracted from the Scopus and WoSCC databases, respectively. The publications have shown rapid growth since 2006, partly owing to the largest research hotspot appearing since then, “quinolinic acid.” All the top five most relevant journals were in the neuropsychiatry field, such as Brain Behavior and Immunity. The United States and Innsbruck Medical University were the most influential country and institute, respectively. Journal co-citation analysis showed a strong tendency toward co-citation of research in the psychiatry field. Reference co-citation analys...