Ligand-Controlled Regiodivergent Asymmetric [5 + 2] and [3 + 2] Annulations of Vinyl Indoloxazolidones Catalyzed by Palladium

作者：Zhi Gang Zhao, Xing‐Xing Yang, Guang‐Yao Ran, Qin Ouyang, Wei Du, Ying‐Chun Chen · 发表于：Organic Letters · 年份：2021 · DOI：10.1021/acs.orglett.1c01507 · 被引用次数：28 · 研究领域：Catalytic C–H Functionalization Methods、Asymmetric Synthesis and Catalysis、Synthetic Organic Chemistry Methods

Here, we present palladium-catalyzed regiodivergent asymmetric annulations of vinyl indoloxazolidones, which can act as 1,5-carbodipoles or 1,3-carbodipoles by tuning the chiral ligands and conditions, in the assemblies with sulfamate-derived cyclic imines and even activated alkenes. A diversity of polycyclic products are generally constructed with high regio- and enantioselectivity.