Molecular Mechanisms of Chondrocyte Proliferation and Differentiation

作者：Hui Chen, Xiaoning Tan, Shi Hu, Ren-Qin Liu, Lihong Peng, Yongmin Li, Ping Wu · 发表于：Frontiers in Cell and Developmental Biology · 年份：2021 · DOI：10.3389/fcell.2021.664168 · 被引用次数：168 · 研究领域：Osteoarthritis Treatment and Mechanisms、Cancer-related gene regulation、Cancer-related molecular mechanisms research

Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood vessels, lymph, and nerve tissues. Repair of cartilage injury is mainly achieved by stimulating chondrocyte proliferation and extracellular matrix (ECM) synthesis. Cartilage homeostasis involves the regulation of multiple growth factors and the transduction of cellular signals. It is a very complicated process that has not been elucidated in detail. In this review, we summarized a variety of signaling molecules related to chondrocytes function. Especially, we described the correlation between chondrocyte-specific regulatory factors and cell signaling molecules. It has potential significance for guiding the treatment of cartilage injury.