Safety and efficacy of drug-eluting bead transarterial chemoembolization with CalliSpheres® microsphere for hepatocellular carcinoma with portal vein tumor thrombus: a preliminary study

作者：Tan‐Yang Zhou, Sheng-Qun Chen, Hongliang Wang, Sheng-Ming Weng, Guan‐Hui Zhou, Yuelin Zhang, Chun‐Hui Nie, Tong‐Yin Zhu, Baoquan Wang, Zi‐Niu Yu, Jing Li, Feng Chen, Junhui Sun · 发表于：Journal of Cancer · 年份：2021 · DOI：10.7150/jca.54650 · 被引用次数：19 · 研究领域：Hepatocellular Carcinoma Treatment and Prognosis、Liver Disease and Transplantation、Cancer Mechanisms and Therapy

Objective: To prospectively evaluate the safety and therapeutic effectiveness of drug-eluting beads transcatheter arterial chemoembolization (DEB-TACE) with CalliSpheres microsphere (CSM) for the treatment of hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT), and to analyze the prognostic factors. Method: Between November 2015 and November 2017, consecutive 58 HCC patients with PVTT who received DEB-TACE with CSM treatment were prospectively enrolled in this study. The demographic characteristics, adverse events (AEs) and treatment response were collected. Overall survival (OS) and progression-free survival (PFS) were calculated using the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were performed to determine the independent factors correlated with OS.