Piezo Channels: Awesome Mechanosensitive Structures in Cellular Mechanotransduction and Their Role in Bone

作者：Xia Xu, Shuyu Liu, Hua Liu, Kang Ru, Yunxian Jia, Zixiang Wu, Shujing Liang, Zarnaz Khan, Zhihao Chen, Airong Qian, Lifang Hu · 发表于：International Journal of Molecular Sciences · 年份：2021 · DOI：10.3390/ijms22126429 · 被引用次数：108 · 研究领域：Erythrocyte Function and Pathophysiology、Ion channel regulation and function、Blood properties and coagulation

Piezo channels are mechanosensitive ion channels located in the cell membrane and function as key cellular mechanotransducers for converting mechanical stimuli into electrochemical signals. Emerged as key molecular detectors of mechanical forces, Piezo channels' functions in bone have attracted more and more attention. Here, we summarize the current knowledge of Piezo channels and review the research advances of Piezo channels' function in bone by highlighting Piezo1's role in bone cells, including osteocyte, bone marrow mesenchymal stem cell (BM-MSC), osteoblast, osteoclast, and chondrocyte. Moreover, the role of Piezo channels in bone diseases is summarized.