Avoiding Regrettable Substitutions: Green Toxicology for Sustainable Chemistry

作者：Alexandra Maertens, Emily Golden, Thomas Härtung · 发表于：ACS Sustainable Chemistry & Engineering · 年份：2021 · DOI：10.1021/acssuschemeng.0c09435 · 被引用次数：135 · 研究领域：Chemistry and Chemical Engineering、Effects and risks of endocrine disrupting chemicals、Pharmaceutical and Antibiotic Environmental Impacts

Green chemistry seeks to design less hazardous chemicals, but many of the efforts to replace chemicals have resulted in so-called "Regrettable Substitutions", when a chemical with an unknown or unforeseen hazard is used to replace a chemical identified as problematic. Here, we discuss the literature on regrettable substitution and focus on an oft-mentioned case, Bisphenol A, which was replaced with Bisphenol S-and the lessons that can be learned from this history. In particular, we focus on how Green Toxicology can offer a way to make better substitutions.