Recurrent Wheezing and Asthma After Respiratory Syncytial Virus Bronchiolitis

作者：Yunlian Zhou, Lin Tong, Mengyao Li, Yingshuo Wang, Lanxin Li, Dehua Yang, Yuanyuan Zhang, Zhimin Chen · 发表于：Frontiers in Pediatrics · 年份：2021 · DOI：10.3389/fped.2021.649003 · 被引用次数：32 · 研究领域：Respiratory viral infections research、Neonatal Respiratory Health Research、Congenital Diaphragmatic Hernia Studies

Background: Respiratory syncytial virus (RSV) is the most common pathogen of acute bronchiolitis in children, which sometimes triggers the development of recurrent wheezing and increases the risk of childhood asthma. Methods: We enrolled 425 children who were diagnosed with RSV-infected bronchiolitis at the department of pulmonology, Children's Hospital Zhejiang University School of Medicine in 2011. Long-term follow-up was performed to explore the consequence of bronchiolitis on subsequent recurrent wheezing and asthma. Results: Of 425 patients, 266 cases completed the entire follow-up, the mean age of onset was 4.9 (3.3) months, and the male-to-female ratio was 2.5. The mean birth weight of all patients was 3.22 (0.63) kg, and the number of patients who had a history of cesarean section was 148. According to the outcome of follow-up, 36 were in the recurrent wheezing (RW) group, 65 were in the asthma (AS) group, and the remaining 165 were in the completely recovered (CR) group. The age of onset was older and the birth weights were higher in the AS group than those in the CR group ( P < 0.05). And the higher proportion of cesarean sections was higher in the RW group than that in the CR group ( P < 0.05). Furthermore, we found a remarkable increasing of serum IgE in the AS groups than that in the CR group ( P < 0.01). Multiple logistic regression analysis showed that the cesarean section was the risk factor for the development of recurrent wheezing and th...