Congenital biliary atresia is correlated with disrupted cell junctions and polarity caused by Cdc42 insufficiency in the liver

作者：Yongjie Zhou, Hongjie Ji, Qing Xu, Xiaoyun Zhang, Xiaoyue Cao, Yuwei Chen, Mingyang Shao, Zhenru Wu, Jie Zhang, Changli Lu, Jiayin Yang, Yujun Shi, Hong Bu · 发表于：Theranostics · 年份：2021 · DOI：10.7150/thno.49116 · 被引用次数：24 · 研究领域：Pediatric Hepatobiliary Diseases and Treatments、Infant Nutrition and Health、Congenital Anomalies and Fetal Surgery

Our results illustrate that BA is closely correlated with the impaired assembly of cell junction and polarity complexes in liver cells, which is likely caused by Cdc42 insufficiency and aggravated by bile acid corrosion.