Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

作者：Wilfredo Francisco Garcia-Beltran, Evan Christopher Lam, Kerri St. Denis, Adam D. Nitido, Zeidy H. Garcia, Blake Marie Hauser, Jared E. Feldman, Maia Pavlovic, David J. Gregory, Mark C. Poznansky, Alex Sigal, Aaron G. Schmidt, Anthony John Iafrate, Vivek Naranbhai, Alejandro Benjamin Balazs · 发表于：Cell · 年份：2021 · DOI：10.1016/j.cell.2021.04.006 · 被引用次数：328 · 研究领域：SARS-CoV-2 and COVID-19 Research、interferon and immune responses、vaccines and immunoinformatics approaches

(Cell 184, 2372–2383.e1–e9; April 29, 2021) Due to a production error, the received date for this article was originally published as February 12, 2020, but the correct date is February 12, 2021. This error has been corrected online and in the print version. The journal apologizes for any confusion. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunityGarcia-Beltran et al.CellMarch 12, 2021In BriefAnalyses of sera from individuals vaccinated with one or two doses of mRNA vaccines against 10 circulating variants of SARS-CoV-2 show that P.1 and B.1.351 in particular exhibit limited neutralization by vaccine-induced humoral immunity. This escape was found to be largely mediated by mutations in the receptor-binding domain of SARS-CoV-2 spike. Full-Text PDF Open Archive