The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming

作者：Noymar Luque‐Campos, Felipe A. Bustamante-Barrientos, Carolina Pradenas, C.M. Garcia, María Jesús Araya, Candice Bohaud, Rafael Contreras‐López, Roberto Elizondo‐Vega, Farida Djouad, Patricia Luz‐Crawford, Ana María Vega-Letter · 发表于：Frontiers in Immunology · 年份：2021 · DOI：10.3389/fimmu.2021.624746 · 被引用次数：75 · 研究领域：Immune cells in cancer、Phagocytosis and Immune Regulation、Autophagy in Disease and Therapy

Mesenchymal stem cells (MSCs) are multipotent adult stromal cells widely studied for their regenerative and immunomodulatory properties. They are capable of modulating macrophage plasticity depending on various microenvironmental signals. Current studies have shown that metabolic changes can also affect macrophage fate and function. Indeed, changes in the environment prompt phenotype change. Therefore, in this review, we will discuss how MSCs orchestrate macrophage's metabolic plasticity and the impact on their function. An improved understanding of the crosstalk between macrophages and MSCs will improve our knowledge of MSC's therapeutic potential in the context of inflammatory diseases, cancer, and tissue repair processes in which macrophages are pivotal.