Photocatalytic Cyclization/Defluorination Domino Sequence to Access 3-Fluoro-1,5-dihydro-2 H -pyrrol-2-one Scaffold

作者：Zhipeng Ye, Yuan‐Zhuo Hu, Jianping Guan, Kai Chen, Fang Liu, Jie Gao, Jun‐An Xiao, Hao‐Yue Xiang, Xiaoqing Chen, Hua Yang · 发表于：Organic Letters · 年份：2021 · DOI：10.1021/acs.orglett.1c01477 · 被引用次数：33 · 研究领域：Fluorine in Organic Chemistry、Catalytic C–H Functionalization Methods、Cyclopropane Reaction Mechanisms

We herein report an unprecedented photoinduced cyclization/defluorination domino process of N -allylbromodifluoroacetamide with cyclic secondary amines. Consequently, a wide array of valuable 3-fluoro-1,5-dihydro-2 H -pyrrol-2-ones were facilely prepared from readily available starting materials under mild conditions. Preliminary mechanistic investigations suggest that a radical chain propagation and amine-promoted defluorination pathway are presumably involved in this transformation.