Repair of DNA double-strand breaks in RNAPI- and RNAPII-transcribed loci

作者：Emma Lesage, Thomas Clouaire, Gaëlle Legube · 发表于：DNA repair · 年份：2021 · DOI：10.1016/j.dnarep.2021.103139 · 被引用次数：18 · 研究领域：DNA Repair Mechanisms、RNA modifications and cancer、Molecular Biology Techniques and Applications

DNA double-strand breaks (DSBs) are toxic lesions triggered not only by environmental sources, but also by a large number of physiological processes. Of importance, endogenous DSBs frequently occur in genomic loci that are transcriptionally active. Recent work suggests that DSBs occurring in transcribed loci are handled by specific pathway(s) that entail local transcriptional repression, chromatin signaling, the involvement of RNA species and DSB mobility. In this Graphical Review we provide an updated view of the "Transcription-Coupled DSB Repair" (TC-DSBR) pathway(s) that are mounted at DSBs occurring in loci transcribed by RNA Polymerase I (RNAPI) or RNA Polymerase II (RNAPII), highlighting differences and common features, as well as yet unanswered questions.