Pancreatic neuroendocrine carcinoma in a pregnant woman: A case report and review of the literature

作者：Liping Gao, Gui-Xiang Kong, Xiang Wang, Huimin Ma, Feifei Ding, Tingdong Li · 发表于：World Journal of Clinical Cases · 年份：2021 · DOI：10.12998/wjcc.v9.i17.4327 · 被引用次数：6 · 研究领域：Neuroendocrine Tumor Research Advances、Intraperitoneal and Appendiceal Malignancies、Multiple and Secondary Primary Cancers

BACKGROUND: Portal venous thromboembolism caused by malignant pancreatic neuroendocrine tumor metastasis, as the initial presentation of portal hypertension and upper gastrointestinal bleeding, is a rare entity. To our knowledge, there are no reports of this entity in pregnant women. We describe a case of pancreatic neuroendocrine carcinoma during pregnancy with hematemesis and hematochezia as the initial presentation and review the literature to analyze the demographic, clinical, and pathological features to provide a reference for clinical diagnosis and treatment. CASE SUMMARY: A 40-year-old woman presented with hematemesis and hematochezia at 26-wk gestation; she had no other remarkable medical history. The physical examination revealed normal vital signs, an anemic appearance, and lower abdominal distension. Abdominal color Doppler ultrasonography showed portal vein thrombosis, splenomegaly, intrauterine pregnancy, and intrauterine fetal death. Esophagogastroduodenoscopy revealed esophageal and gastric varicose veins and portal hypertensive gastropathy. Contrast-enhanced computed tomography demonstrated multiple emboli formation in the portal and splenic veins, multiple round shadows in the liver with a slightly lower density, portal vein broadening, varicose veins in the lower esophagus and gastric fundus, splenomegaly, bilateral pleural effusion, ascites and pelvic effusion, broadening of the common bile duct, and increased uterine volume. According to the results of Po...