The prenatal phase of retinopathy of prematurity

作者：Olaf Dammann, José Carlos Rivera, Sylvain Chemtob · 发表于：Acta Paediatrica · 年份：2021 · DOI：10.1111/apa.15945 · 被引用次数：35 · 研究领域：Retinopathy of Prematurity Studies、Neonatal Respiratory Health Research、Preterm Birth and Chorioamnionitis

AIM: To explore the current literature on prenatal inflammation-associated risk factors for retinopathy of prematurity (ROP). METHODS: Subjective summary of selected experimental and epidemiological publications that support the authors' central hypothesis that the aetiology of ROP begins before birth. RESULTS: Based on current evidence we suggest that, contrary to current aetiological models, the process of ROP development begins with a prephase in utero. This beginning is likely initiated by inflammatory responses that are associated with intrauterine infection. CONCLUSION: We propose a novel aetio-pathogenetic model of ROP and suggest that the effects of postnatal exposure to inflammatory stressors (resulting from infection or hyperoxia or both) as well as those of other pre- and postnatal contributors to the complex pathogenesis of ROP might be modified by the prenatal phase of the disease.