Patient-Reported Toxicity and Quality-of-Life Profiles in Patients With Head and Neck Cancer Treated With Definitive Radiation Therapy or Chemoradiation

作者：L. Van den Bosch, Hans Paul van der Laan, A. van der Schaaf, Sjoukje F. Oosting, György B. Halmos, Max J. H. Witjes, Edwin Oldehinkel, Tineke W.H. Meijer, Johanna G.M. van den Hoek, Roel J.H.M. Steenbakkers, Johannes A. Langendijk · 发表于：International Journal of Radiation Oncology*Biology*Physics · 年份：2021 · DOI：10.1016/j.ijrobp.2021.05.114 · 被引用次数：58 · 研究领域：Head and Neck Cancer Studies、Oral health in cancer treatment、Oral Health Pathology and Treatment

PURPOSE: Radiation therapy is an effective but burdensome treatment for head and neck cancer (HNC). We aimed to characterize the severity and time pattern of patient-reported symptoms and quality of life in a large cohort of patients with HNC treated with definitive radiation therapy, with or without systemic treatment. METHODS AND MATERIALS: A total of 859 patients with HNC treated between 2007 and 2017 prospectively completed the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Head and Neck Cancer module (QLQ-HN35) and Core Quality of Life Questionnaire (QLQ-C30) at regular intervals during and after treatment for up to 5 years. Patients were classified into 3 subgroups: early larynx cancer, infrahyoideal cancer, and suprahyoideal cancer. Outcome scales of both questionnaires were quantified per subgroup and time point by means of average scores and the frequency distribution of categorized severity (none, mild, moderate, and severe). Time patterns and symptom severity were characterized. Toxicity profiles were compared using linear mixed model analysis. Additional toxicity profiles based on age, human papillomavirus status, treatment modality, smoking status, tumor site, and treatment period were characterized as well. RESULTS: The study population consisted of 157 patients with early larynx cancer, 304 with infrahyoideal cancer, and 398 with suprahyoideal cancer. The overall questionnaire response rate was 83%. Generally, t...