Eosinophilic inflammation promotes CCL6-dependent metastatic tumor growth

作者：Fei Li, Xufei Du, Fen Lan, Na Li, Chao Zhang, Chen Zhu, Xiaohui Wang, Yicheng He, Zhehua Shao, Hạixia Chen, Man Luo, Wen Li, Zhihua Chen, Songmin Ying, Huahao Shen · 发表于：Science Advances · 年份：2021 · DOI：10.1126/sciadv.abb5943 · 被引用次数：69 · 研究领域：Immune Cell Function and Interaction、Eosinophilic Disorders and Syndromes、Immune cells in cancer

Tg mice remarkably attenuates bone metastasis. Moreover, inhibition of C-C chemokine receptor 1 (CCR1, the receptor of CCL6) in tumor cells reduces tumor cell migration and metastasis. Thus, our study identifies a CCL6-dependent prometastatic activity of eosinophils, which can be inhibited by targeting CCR1 and represent an approach to preventing metastatic disease.