Role of IL-6 in the regulation of neuronal development, survival and function

作者：Kai K. Kummer, Maximilian Zeidler, Theodora Kalpachidou, Michaela Kress · 发表于：Cytokine · 年份：2021 · DOI：10.1016/j.cyto.2021.155582 · 被引用次数：279 · 研究领域：Neuroinflammation and Neurodegeneration Mechanisms、Cytokine Signaling Pathways and Interactions、Stress Responses and Cortisol

The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial and destructive potentials. It can exert opposing actions triggering either neuron survival after injury or causing neurodegeneration and cell death in neurodegenerative or neuropathic disorders. Importantly, neurons respond differently to IL-6 and this critically depends on their environment and whether they are located in the peripheral or the central nervous system. In addition to its hub regulator role in inflammation, IL-6 is recently emerging as an important regulator of neuron function in health and disease, offering exciting possibilities for more mechanistic insight into the pathogenesis of mental, neurodegenerative and pain disorders and for developing novel therapies for diseases with neuroimmune and neurogenic pathogenic components.