Bile Salt Hydrolases: At the Crossroads of Microbiota and Human Health

作者：Mélanie Bourgin, Aïcha Kriaa, Héla Mkaouar, Vincent Mariaule, Amin Jablaoui, Emmanuelle Maguin, Moez Rhimi · 发表于：Microorganisms · 年份：2021 · DOI：10.3390/microorganisms9061122 · 被引用次数：140 · 研究领域：Gut microbiota and health、Clostridium difficile and Clostridium perfringens research、Pancreatitis Pathology and Treatment

The gut microbiota has been increasingly linked to metabolic health and disease over the last few decades. Several factors have been suggested to be involved in lipid metabolism and metabolic responses. One mediator that has gained great interest as a clinically important enzyme is bile salt hydrolase (BSH). BSH enzymes are widely distributed in human gastrointestinal microbial communities and are believed to play key roles in both microbial and host physiology. In this review, we discuss the current evidence related to the role of BSHs in health and provide useful insights that may pave the way for new therapeutic targets in human diseases.