Pembrolizumab alone or combined with chemotherapy versus chemotherapy as first-line therapy for advanced urothelial carcinoma (KEYNOTE-361): a randomised, open-label, phase 3 trial

作者：Thomas Powles, Tibor Csőszi, Mustafa Özgüroğlu, Nobuaki Matsubara, Lajos Géczi, Susanna Cheng, Yves Fradet, Stéphane Oudard, Christof Vulsteke, Rafael Morales‐Barrera, Aude Fléchon, Şeyda Gündüz, Yohann Loriot, Alejo Rodríguez‐Vida, Ronac Mamtani, Evan Y. Yu, Kijoeng Nam, Kentaro Imai, Blanca Homet Moreno, Ajjai Alva, D. Cascallar, Mirta Varela, Mauricio Fernández Lazzaro, Diego Kaen, Gabriela Gatica, David Hugo Flores, Agustín Falco, Matias Molina, F. Van Aelst, Christof Vulsteke, Brieuc Sautois, Jean‐Pascal Machiels, Denis Schallier, Leandro Brust, Liane Rapatoni, Sérgio Jobim Azevedo, GISELE LOPES MARINHO, João Paulo Holanda Soares, Carlos Dzik, Jamile Almeida Silva, André P. Fay, Joel Gingerich, Yves Fradet, Cristiano Ferrario, Kylea Potvin, Marie Vanhuyse, Mahmoud Abdelsalam, Susanna Cheng, Christian Caglevic, Felipe Reyes, José Luis Leal, Francisco Francisco, Carolina Ibáñez, Florence Joly, Brigitte Laguerre, Sylvain Ladoire, Aude Fléchon, Delphine Topart, Olivier Huillard, Stéphane Oudard, Marine Gross‐Goupil, Stéphane Culine, Yohann Loriot, Gwénaëlle Gravis, Peter Reichardt, Margitta Retz, Jan Herden, David G. Pfister, Carsten Ohlman, Michael Stöeckle, Manfred P. Wirth, Anja Lorch, Guenter Niegisch, Peter J. Goebell, Martin Boegemann, Axel S. Merseburger, Georgios Gakis, Jens Bedke, Andreas Neisius, Christian A. Thomas, Thomas Hoefner, András Telekes, Judit Kósa, János Révész, Gyorgy Bodoky, Tibor Csőszi, András Csejtei, Lajos Géczi, Ágnes Ruzsa, Zsuzsanna Kolonics, József Erfán, Ray McDermott, Richard Bambury, Avishay Sella, Stephen Jay Frank, Daniel Kejzman, Olesya Goldman, Eli Rosenbaum, Avivit Peer, Raanan Berger, Keren Rouvinov, David Sarid, Satoshi Fukasawa, Gaku Arai, Akito Yamaguchi, Akira Yokomizo, Tatsuya Takayama, Hidefumi Kinoshita, Eiji Kikuchi, Ryuichi Mizuno, Yasuhisa Fujii, Naoto Sassa, Yoshihisa Matsukawa, Kiyohide Fujimoto, Nobuaki Matsubara, Toshiki Tanikawa, Yoshihiko Tomita, Kazuo Nishimura, Masao Tsujihata, Masafumi Oyama, Naoya Masumori, Hiro‐omi Kanayama, Toshimi Takano, Yuji Miura, Jun Miyazaki, Akira Joraku, Tomokazu Kimura, Yoshiaki Yamamoto, Kazuki Kobayashi, Ronald de Wit, Maureen J.B. Aarts, Winald R. Gerritsen, Maartje Los, Laurens V. Beerepoot, А. А. Измайлов, Sergey Gorelov, B. Yа. Alekseev, Andrey Semenov, Vladimir Kostorov, С. М. Алексеев, A. V. Zyryаnov, Vasiliy Nikolaevich Oschepkov, Vladimir A. Shidin, Vladimir Vladimirov, Rustem Gafanov, Petr Karlov, David Anderson, Lucinda Shepherd, Graham Cohen, Bernardo Louis Rapoport, Paul Ruff, Nari Lee, Woo Kyun Bae, Hyo Jin Lee, Urbano Anido Herranz, Alejo Rodríguez‐Vida, Rafael Morales‐Barrera, Enrique Grande, Teresa Alonso Gordoa, Josep Guma Padro, D. Castellano Gauna, José Ángel Arranz, José Muñoz-Langa, Regina Gironés Sarrió, Á. Montesa Pino, María José Juan-Fita, Yu‐Li Su, Yung‐Chang Lin, Wen-Pin Su, Ying‐Chun Shen, Yen‐Hwa Chang, Yi-Hsiu Huang, Virote Sriuranpong, Phichai Chansriwong, Vichien Srimuninnimit, Pongwut Danchaivijitr, Hüseyin Abalı, Sinan Yavuz, Özgür Özyılkan, Mehmet Alı Nahıt Şendur, Meltem Ekenel, Mustafa Özgüroğlu, Çağatay Arslan, Şeyda Gündüz, Mustafa Özdoğan, Alison Birtle, Thomas Powles, Robert Huddart, Maria De Santis, Anjali Zarkar, Linda Evans, Syed A. Hussain, Christopher DiSimone, Antonio F Muina, Peter N. Schlegel, Haresh Jhangiani, Michael R. Harrison, Dennis Slater, David J. Wright, Ivor Percent, Jianqing Lin, Clara Hwang, Ronac Mamtani, Sumati Gupta, Madhuri Bajaj, Robert Galamaga, John Eklund, James A. Wallace, Mikhail Shtivelband, Jason Suh, Nafisa Burhani, Matthew Eadens, Krishna S. Gunturu, Earle F. Burgess, John Wong, Arvind Chaudhry, Peter J. Van Veldhuizen, Stephanie L. Graff, Christian A. Thomas, Ian D. Schnadig, Benedito A. Carneiro, Maha Hussain, Alicia K. Morgans, John T Fitzharris, Ira A. Oliff, Jacqueline Vuky, Ralph J. Hauke, Ari David Baron, Monika Joshi, Britt Haley Bolemon, Peter Jiang, Anthony Mega, Maurice Markus, Nicklas Pfanzelter, William Lawler, Patrick Cobb, Jay Courtright, Sharad Jain, Gurjyot K. Doshi, Vijay Gunuganti, Oliver A. Sartor, Scott Cole, Hani Babiker, Edward Uchio, Alexandra Drakaki, Heather D. Mannuel, Ajjai Alva, Elizabeth A. Guancial, Chunkit Fung, Anthony Charles, Robert J. Amato, Yull Arriaga, I. Alex Bowman, Steven Ades, Robert Dreicer, Evan Y. Yu, David I. Quinn, Mark T. Fleming · 发表于：The Lancet Oncology · 年份：2021 · DOI：10.1016/s1470-2045(21)00152-2 · 被引用次数：655 · 研究领域：Bladder and Urothelial Cancer Treatments、Cancer Immunotherapy and Biomarkers、Esophageal Cancer Research and Treatment