κ-opioid receptor stimulation alleviates rat vascular smooth muscle cell calcification via PFKFB3-lactate signaling

作者：Jin Niu, Chen Wu, Min Zhang, Zhen Yang, Zhenhua Liu, Feng Fu, Jun Li, Na Feng, Xiaoming Gu, Shumiao Zhang, Yali Liu, Rong Fan, Juan Li, Jianming Pei · 发表于：Aging · 年份：2021 · DOI：10.18632/aging.203050 · 被引用次数：22 · 研究领域：Parathyroid Disorders and Treatments、Caveolin-1 and cellular processes、Vitamin K Research Studies

. Collectively, our experiments show that κ-opioid receptor activation inhibits VSMC calcification by reducing PFKFB3 expression and lactate content, providing a potential drug target and strategy for the clinical treatment of vascular calcification.