The role of surgical resection in primary central nervous system lymphoma: a single-center retrospective analysis of 70 patients

作者：Shiqiang Wu, Junwen Wang, Weihua Liu, Feng Hu, Kai Zhao, Wei Jiang, Ting Lei, Kai Shu · 发表于：BMC Neurology · 年份：2021 · DOI：10.1186/s12883-021-02227-3 · 被引用次数：37 · 研究领域：CNS Lymphoma Diagnosis and Treatment、Glioma Diagnosis and Treatment、Lymphoma Diagnosis and Treatment

BACKGROUND: The aim of this study was to evaluate the effect of surgical resection and stereotactic biopsy on the complication rate, progression-free survival (PFS) and overall survival (OS) of 70 patients diagnosed at a single institution with primary central nervous system lymphoma (PCNSL) and to explore the predictors of selection for resection and the prognostic factors of PCNSL. METHODS: A retrospective analysis was performed of 70 patients with PCNSL that was diagnosed by surgical resection or stereotactic brain biopsy in our department from January 2013 to May 2019. We divided the patients into two groups: a resection group (n = 28) and a stereotactic biopsy group (n = 42). Data on clinical characteristics, imaging findings, complication rates, PFS and OS were retrospectively reviewed and compared between these two groups. We also analysed the predictors of selection for resection and prognostic factors of PCNSL by multivariate analysis. RESULTS: The median age was 53.3 ± 14.3 years, and there was a male predominance with a sex ratio of 1.33:1. The most common clinical manifestation was a headache. The complication rate in the resection group was 10.7% versus 7.1% in the stereotactic biopsy group, and there was no statistically significant difference. The rate of improvement in symptoms of the resection group was significantly higher than that of the stereotactic biopsy group. Multivariable analysis identified a single tumour and not involving deep structures as predic...