MicroRNAs: immune modulators in cancer immunotherapy

作者：Yun Xing, Zhiqiang Wang, Zhou Lu, Jie Xia, Zhangjuan Xie, Mengxia Jiao, Ronghua Liu, Yiwei Chu · 发表于：Immunotherapy Advances · 年份：2021 · DOI：10.1093/immadv/ltab006 · 被引用次数：39 · 研究领域：MicroRNA in disease regulation、Circular RNAs in diseases、Extracellular vesicles in disease

MicroRNA (miRNA) is a class of endogenous small non-coding RNA of 18-25 nucleotides and plays regulatory roles in both physiological and pathological processes. Emerging evidence support that miRNAs function as immune modulators in tumors. MiRNAs as tumor suppressors or oncogenes are also found to be able to modulate anti-tumor immunity or link the crosstalk between tumor cells and immune cells surrounding. Based on the specific regulating function, miRNAs can be used as predictive, prognostic biomarkers, and therapeutic targets in immunotherapy. Here, we review new findings about the role of miRNAs in modulating immune responses, as well as discuss mechanisms underlying their dysregulation, and their clinical potentials as indicators of tumor prognosis or to sensitize cancer immunotherapy.