Serum Resistin Levels in Adult Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis

作者：Dongli Han, Jie Chen, Shousheng Liu, Zengzhi Zhang, Zhenzhen Zhao, Wenwen Jin, Yongning Xin · 发表于：Journal of Clinical and Translational Hepatology · 年份：2021 · DOI：10.14218/jcth.2021.00018 · 被引用次数：16 · 研究领域：Adipokines, Inflammation, and Metabolic Diseases、Liver Disease Diagnosis and Treatment、Nutrition and Health in Aging

BACKGROUND AND AIMS: Previous studies reported that serum resistin levels were remarkably changed in patients with nonalcoholic fatty liver disease (NAFLD) but the conclusions were inconsistent. The aim of this study was to investigate accurate serum resistin levels in adult patients with NAFLD. METHODS: A complete literature research was conducted in the PubMed, Embase, and Cochrane Library databases, and all the available studies up to 7 May 2020 were reviewed. The pooled standardized mean difference (SMD) values were calculated to investigate the serum resistin levels in patients with NAFLD and healthy controls. RESULTS: =0.00%). Furthermore, subgroup and sensitivity analyses suggested that heterogeneity did not affect the results of meta-analysis. CONCLUSIONS: This meta-analysis investigated the serum resistin levels in adult patients with NAFLD comprehensively. Patients with NAFLD had higher serum resistin levels and patients with NASH had lower serum resistin levels than healthy controls. Serum resistin could serve as a potential biomarker to predict the development risk of NAFLD.