Net flux of nonesterified fatty acids, cholesterol, triacylglycerol, and glycerol across the portal-drained viscera and liver of pregnant ewes.

作者：H. C. Freetly, Calvin L. Ferrell · 发表于：Journal of Animal Science · 年份：2000 · DOI：10.2527/2000.7851380x · 被引用次数：20 · 研究领域：Reproductive Physiology in Livestock、Ruminant Nutrition and Digestive Physiology、Fatty Acid Research and Health

The objective of this study was to determine the pattern of nutrient flux across portal-drained viscera (PDV) and liver in ewes with varying numbers of fetuses. Catheters were placed in the hepatic portal vein, a branch of the hepatic vein, a mesenteric vein, and the abdominal aorta of each ewe. Plasma flow and net cholesterol, nonesterified fatty acids (NEFA), and glycerol release across the PDV and liver were determined prior to exposure to rams. Ewes were subsequently mated. Two ewes were not pregnant, six ewes gave birth to singles, and 11 ewes gave birth to twins. Additional measurements were taken 103, 82, 61, 39, 19, and 6 d before parturition. There was a net PDV uptake of nonesterified cholesterol in the nonpregnant ewes and a net release in the ewes with singles and twins. Net nonesterified cholesterol hepatic release did not differ with days from parturition (P = .77). There was a net hepatic release of nonesterified cholesterol in the ewes with twins and a net hepatic uptake in the ewes with singles and in nonpregnant ewes (P = .03). There was a net PDV release of NEFA; however, it did not differ with litter size (P = .59) or days from parturition (P = .63). Hepatic NEFA uptake increased with litter size (P = .03) and increased as gestation progressed (P = .006). There was an interaction (P = .04) between litter size and days from parturition for net PDV glycerol release. Net PDV glycerol release in the nonpregnant ewes decreased over time, but release in pregnant...