In vitro biocompatibility and bioactivity of calcium silicate‑based bioceramics in endodontics (Review)

作者：Wencheng Song, Shue Li, Qingming Tang, Lili Chen, Zhenglin Yuan · 发表于：International Journal of Molecular Medicine · 年份：2021 · DOI：10.3892/ijmm.2021.4961 · 被引用次数：90 · 研究领域：Endodontics and Root Canal Treatments、Spine and Intervertebral Disc Pathology、Dental Radiography and Imaging

Calcium silicate‑based bioceramics have been applied in endodontics as advantageous materials for years. In addition to excellent physical and chemical properties, the biocompatibility and bioactivity of calcium silicate‑based bioceramics also serve an important role in endodontics according to previous research reports. Firstly, bioceramics affect cellular behavior of cells such as stem cells, osteoblasts, osteoclasts, fibroblasts and immune cells. On the other hand, cell reaction to bioceramics determines the effect of wound healing and tissue repair following bioceramics implantation. The aim of the present review was to provide an overview of calcium silicate‑based bioceramics currently applied in endodontics, including mineral trioxide aggregate, Bioaggregate, Biodentine and iRoot, focusing on their in vitro biocompatibility and bioactivity. Understanding their underlying mechanism may help to ensure these materials are applied appropriately in endodontics.