Toxoplasma gondii Matrix Antigen 1 Is a Secreted Immunomodulatory Effector

作者：Tadakimi Tomita, Debanjan Mukhopadhyay, Bing Han, Rama Yakubu, Vincent Tu, Joshua Mayoral, Tatsuki Sugi, Yanfen Ma, Jeroen P. J. Saeij, Louis M. Weiss · 发表于：mBio · 年份：2021 · DOI：10.1128/mbio.00603-21 · 被引用次数：33 · 研究领域：Toxoplasma gondii Research Studies、Herpesvirus Infections and Treatments、Rabies epidemiology and control

Toxoplasma gondii is an Apicomplexan that infects a third of humans, causing encephalitis in AIDS patients and intellectual disabilities in congenitally infected patients. We determined that one of the cyst matrix proteins, MAG1, which had been thought to be an innate structural protein, can be secreted into the host cell and suppress the host immune reaction.