Flexible, high-resolution thin-film electrodes for human and animal neural research

作者：Chia‐Han Chiang, Charles Wang, Katrina Barth, Shervin Rahimpour, Michael Trumpis, Suseendrakumar Duraivel, Iakov Rachinskiy, Agrita Dubey, Katie Wingel, Megan K. Wong, Nicholas S Witham, Thomas M. Odell, Virginia Woods, Brinnae Bent, Werner Doyle, Daniel Friedman, E. Bihler, Christopher F. Reiche, Derek G. Southwell, Michael M. Haglund, Allan H. Friedman, Shivanand P. Lad, Sasha Devore, Orrin Devinsky, Florian Solzbacher, Bijan Pesaran, Gregory B. Cogan, Jonathan Viventi · 发表于：Journal of Neural Engineering · 年份：2021 · DOI：10.1088/1741-2552/ac02dc · 被引用次数：53 · 研究领域：Neuroscience and Neural Engineering、EEG and Brain-Computer Interfaces、Neural dynamics and brain function

Abstract Objective. Brain functions such as perception, motor control, learning, and memory arise from the coordinated activity of neuronal assemblies distributed across multiple brain regions. While major progress has been made in understanding the function of individual neurons, circuit interactions remain poorly understood. A fundamental obstacle to deciphering circuit interactions is the limited availability of research tools to observe and manipulate the activity of large, distributed neuronal populations in humans. Here we describe the development, validation, and dissemination of flexible, high-resolution, thin-film (TF) electrodes for recording neural activity in animals and humans. Approach. We leveraged standard flexible printed-circuit manufacturing processes to build high-resolution TF electrode arrays. We used biocompatible materials to form the substrate (liquid crystal polymer; LCP), metals (Au, PtIr, and Pd), molding (medical-grade silicone), and 3D-printed housing (nylon). We designed a custom, miniaturized, digitizing headstage to reduce the number of cables required to connect to the acquisition system and reduce the distance between the electrodes and the amplifiers. A custom mechanical system enabled the electrodes and headstages to be pre-assembled prior to sterilization, minimizing the setup time required in the operating room. PtIr electrode coatings lowered impedance and enabled stimulation. High-volume, commercial manufacturing enables cost-effective...