Renal gluconeogenesis in insulin resistance: A culprit for hyperglycemia in diabetes

作者：Rajni Sharma, Swasti Tiwari · 发表于：World Journal of Diabetes · 年份：2021 · DOI：10.4239/wjd.v12.i5.556 · 被引用次数：41 · 研究领域：Metabolism, Diabetes, and Cancer、Pancreatic function and diabetes、FOXO transcription factor regulation

gluconeogenesis in the post-absorptive phase. However, the rate of renal glucose release excessively increases in diabetes. The rise in renal glucose release in diabetes may contribute to fasting hyperglycemia and increased postprandial glucose levels. Enhanced glucose release by the kidneys and renal expression of the gluconeogenic-enzyme in diabetic rodents and humans further point towards the significance of renal gluconeogenesis. Overall, the available literature suggests that impairment in renal gluconeogenesis in an insulin-resistant state may contribute to hyperglycemia in type 2 diabetes.