Non-origami DNA for functional nanostructures: From structural control to advanced applications

作者：Lan Zhang, Xingyi Ma, Guoqing Wang, Xingguo Liang, Hideyuki Mitomo, Andrew R. Pike, Andrew Houlton, Kuniharu Ijiro · 发表于：Nano Today · 年份：2021 · DOI：10.1016/j.nantod.2021.101154 · 被引用次数：39 · 研究领域：Advanced biosensing and bioanalysis techniques、RNA Interference and Gene Delivery、Dendrimers and Hyperbranched Polymers

The revolutionary idea that DNA can play a non-biological role in a material world has indeed become today’s reality. Although much attentions have recently been paid to “structural DNA nanotechnology” centered on DNA origami, due to the need for DNA computation, hybridization and modification that are usually not easily accessed, reproduced, or manipulated, preparation of nanostructures using DNA origami may have yet set a threshold for researcher to advance their fields with functional nanomaterials. It is suggested that, consisting of a few nucleotides (base pairs), or readily obtained by a simple procedure, non-origami DNA itself has sufficiently rich chemical functionality, and afford sequence-programmed growth of hybrid nano-architectures made of DNA and interactive materials with base-resolution control, and that the potential of non-origami DNA in building functional nanostructures has been underestimated. We have investigated an impressive number of fundamental and application-orientated studies in the late few years, and been preparing the review of the state of research in various subdisciplines of functional nanostructures based on non-origami DNA, which involve fundamental interactions of DNA-inorganic species, DNA nanofabrication, electronic nanodevices, functional metal nanoparticles and chiral nanostructures as well. Applications for these nanostructures have been covered in fields ranging from plasmonic biosensing and electrical nanodevices to optical bioimag...