Acquisition of optimal TFH cell function is defined by specific molecular, positional, and TCR dynamic signatures

作者：Kartika Padhan, Eirini Moysi, Alessandra Noto, Alexander Chassiakos, Khader Ghneim, Maria Maddalena Perra, Sanjana Shah, Vasilis Papaioannou, Giulia Fabozzi, David R. Ambrozak, Antigoni Poultsidi, Μαρία Ιωάννου, Craig Fenwick, Samuel Darko, Daniel C. Douek, Rafick‐Pierre Sékaly, Giuseppe Pantaleo, Richard A. Koup, Constantinos Petrovas · 发表于：Proceedings of the National Academy of Sciences · 年份：2021 · DOI：10.1073/pnas.2016855118 · 被引用次数：25 · 研究领域：T-cell and B-cell Immunology、Immune Cell Function and Interaction、Immunotherapy and Immune Responses

Significance We characterized the heterogeneity of human TFH cells at a cellular, molecular, functional, and positional level and revealed possible mechanistic links between relevant determinants of this heterogeneity. Linking the topology with specific molecular profile and function is a key aspect in the understanding of the role of particular TFH cell subsets in the pathogenesis of relevant diseases and the delivery of optimal help to GC B cells for the development of potent neutralizing antibodies.