Receptor conversion impacts outcomes of different molecular subtypes of primary breast cancer

作者：Weipeng Zhao, Linlin Sun, Guolei Dong, Xiaorui Wang, Yan Jia, Zhongsheng Tong · 发表于：Therapeutic Advances in Medical Oncology · 年份：2021 · DOI：10.1177/17588359211012982 · 被引用次数：34 · 研究领域：Breast Cancer Treatment Studies、Advanced Breast Cancer Therapies、Estrogen and related hormone effects

Background: Although the conversion of clinically used breast cancer biomarkers such as estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) between primary tumors and metastatic lesions is well recognized, data on whether receptor conversion has an effect on therapy management and survival in patients with metastatic breast cancer is limited. This study aimed to investigate the clinical implications of receptor conversion throughout tumor progression. Methods: In total, 2450 patients diagnosed with metastatic breast cancer in Tianjin Medical University Cancer Institute and Hospital were analyzed and 426 female patients with available biopsy results from both primary and metastatic sites were included in this study. We investigated the alteration of ER, PR and HER2 during breast cancer progression and evaluated the therapy management and prognostic value of receptor conversion. Results: The conversion rates of ER, PR, and HER2 between primary tumors and metastasis were 21.1% (McNemar’s test p < 0.001), 33.2% ( p < 0.001), and 11.6% ( p = 0.868), respectively. Evaluation of ER, PR, and HER2 status in multiple consecutive metastases revealed a change in 19.1% ( p > 0.05), 23.5% ( p = 0.021), and 9.8% ( p > 0.05) of patients, respectively. Adjuvant therapy (chemotherapy/endocrine therapy) was related to hormone receptor conversion ( p < 0.05). A statistically significant differential survival associated with hormo...