Mechanism Insight into Rapid Photodriven Sterilization Based on Silver Bismuth Sulfide Quantum Dots

作者：Shengwu Wen, Tianhua Wu, Hui Long, Liying Ke, Sui‐Ping Deng, Langhuan Huang, Jingxian Zhang, Shaozao Tan · 发表于：ACS Applied Materials & Interfaces · 年份：2021 · DOI：10.1021/acsami.1c02761 · 被引用次数：48 · 研究领域：Nanoplatforms for cancer theranostics、Quantum Dots Synthesis And Properties、Advanced Photocatalysis Techniques

Microbial contamination and the prevalence of resistant bacteria is considered a worldwide public health problem. Therefore, recently, great efforts have been made to develop photoresponsive platforms for the simultaneous photodynamic antibacterial (PDA) and photothermal antibacterial (PTA) therapy processes as mediated by specific light. However, owing to the absorption mismatches of the photothermal agents and photodynamic photosensitizers, it has been discovered that many synergistic photoresponsive antibacterial platforms cannot be excited by a single-wavelength light. In this study, silver bismuth sulfide quantum dots (AgBiS 2 QDs) identified from the literature as a near-infrared light (NIR) that triggers bifunctional materials with simultaneous photodynamic and photothermal effects for photoresponsive bacterial killing were used. Specifically, AgBiS 2 QDs were successfully synthesized via a bottom-up approach, using polyethylenimine (PEI) as an assistant molecule. With PEI wrapping, the attachment between the negatively charged membrane surfaces of the bacterial cells and AgBiS 2 QDs was enhanced via the electrostatic interactions. The photodriven antibacterial activity of AgBiS 2 QDs was then investigated against both S. aureus and E. coli . The results revealed a significant reduction in bacterial survival. The killing effect was found to be independent of the AgBiS 2 QDs, and redox potentials controlled the photogenerated electrons that thermodynamically favored the...