Treatment for the Benign Childhood Epilepsy With Centrotemporal Spikes: A Monocentric Study

作者：Miriam Kessi, Fangling Yan, Langui Pan, Baiyu Chen, Eleonore Olatoutou, Dong Li, Fang He, Tibera Rugambwa, Lifen Yang, Jing Peng, Fei Yin · 发表于：Frontiers in Neurology · 年份：2021 · DOI：10.3389/fneur.2021.670958 · 被引用次数：17 · 研究领域：Epilepsy research and treatment、Pharmacological Effects and Toxicity Studies、Neuroscience and Neuropharmacology Research

Background and Purpose: To date, there is no specific treatment guideline for the benign childhood epilepsy with centrotemporal spikes (BECTS). Several countries recommend levetiracetam, carbamazepine, sodium valproate, oxcarbazepine, and lamotrigine as first-line drugs. Nevertheless, some of these drugs are associated with cognitive decline. Available studies that investigated the efficacy of levetiracetam and sodium valproate on BECTS involved small sample sizes. This study aimed to evaluate the efficacy of levetiracetam and sodium valproate on cognition, and to investigate the prognostic factors for BECTS as whole. Methods: Clinical data and treatment status of all patients with BECTS at Xiangya Hospital, Central South University followed from 2008 to 2013 were analyzed retrospectively. Since electrical status epilepticus in sleep (ESES) has been confirmed to play a role in cognitive deterioration, in order to evaluate the response to drugs and their cognitive effects, we created two groups of patients according to the levels of spike wave index (SWI): group 1; 0–50% SWI and group 2; >50% SWI at the last follow up. Results: A total of 195 cases were enrolled: 49.7% received monotherapies, 24.1% duotherapies and 27.2% polytherapies. Medications included; levetiracetam plus other drug (s) (75.9%), levetiracetam alone (32.8%), sodium valproate plus other drug (s) (31.3%), and sodium valproate alone (5.1%). After 2 years of treatment and follow up, 71% of the cases had ...